Aims and Scope

The Open Food Science Journal is an Open Access online journal, which publishes research articles, reviews/mini-reviews, letters and guest edited single topic issues in all important areas of food science and technology including but not limited to:

  • Food Chemistry, Microbiology and Safety
  • Food Engineering
  • Sensory Studies
  • Food Structure and Composition
  • Chemistry, Microbiology and Biotechnology aspects of food
  • Emerging Safety and Toxicological Issues
  • Proteomics, Metabolomics, Nutrigenomics and Chemogenomics of Foods Food Quality And Safety
  • Nutraceuticals, Functional Foods and Functional Ingredients
  • Biophysical analysis of Food / Processing Operations
  • Environmental safety and sustainability aspects of food processing
  • Waste / by-product management in food processing

The Open Food Science Journal, a peer-reviewed journal, is an important and reliable source of current information on recent important developments in the field. The emphasis will be on publishing quality papers rapidly and making them freely available to researchers worldwide.

Editor's Choice

Protective Role of Human Intravenous Immunoglobulin from Influenza A Virus Infection in Mice

Katsuro Hagiwara, Sachiyo Kawami, Yuuko Kato-Mori, Ritsuko Kubota-Koketsu, Muneo Tsujikawa, Takeru Urayama, Mikihiro Yunoki, Kazuo Takahashi, Kazuyoshi Ikuta

Intravenous immunoglobulin (IVIG) has been manufactured from pooled plasma of 10,000 or more units from healthy donors. Recently, we reported that the IVIG manufactured even before the 2009 influenza pandemic contained antibodies reactive to seasonal H1N1 and pandemic H1N1 2009 (H1N1 pdm) viruses. In this study, we used an animal model to evaluate the efficacy of IVIG against influenza infections. A seasonal influenza H1N1 strain (New Caledonia, A/NC/20/99) and an H1N1 pdm strain (A/Osaka/168/2009) were used. The BALB/c and severe combined immunodeficiency mice (SCID; C.B-17/lcr-scid/scid) were also used. Mice inoculated with A/NC/20/99 or A/Osaka/168/2009 were administrated IVIG and monitored for 3 weeks. The administration of IVIG 48 h before and after inoculation with a mouse-adapted seasonal H1N1 virus, resulted in survival rates of 80 and 88%, respectively. The rate among control mice was 30%. In addition, infectivity in lungs from IVIG-treated mice also decreased significantly. Similar effects of IVIG on the survival rate were obtained with H1N1 pdm. Thus, IVIG was shown to be effective against both viruses in mice.

June 12, 2012

Quick Links

Indexing Agencies