The Role of Eph Receptor Tyrosine Kinases and Ephrin Ligands in Hematopoietic Cell Development and Function
Michael J. Ting , Andrew W. Boyd *
Identifiers and Pagination:Year: 2008
First Page: 103
Last Page: 110
Publisher Id: TOHJ-2-103
Article History:Received Date: 25/08/2008
Revision Received Date: 08/09/2008
Acceptance Date: 09/09/2008
Electronic publication date: 07/10/2008
Collection year: 2008
open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
The Eph receptor tyrosine kinases form the largest sub-family of the Receptor tyrosine kinases. Eph receptors interact with membrane bound ligands, termed ephrins. Eph-ephrin interactions have significant roles during mammalian development where they mediate such processes as cell adhesion and migration. Although Eph/ephrin expression is low in adult tissues evidence is accumulating which indicates that Eph and ephrins continue to play significant roles in postembryonic tissues. In this review we describe the current understanding of the function of Eph-ephrin signaling in human and mouse hematopoiesis. Ephs and ephrins have been shown to regulate the differentiation of hematopoietic cells, to direct lymphoid development as well as immune function. Whilst much still remains to be learned about the role of Ephephrin signaling in hematopoieis it is already clear that this system exerts important regulatory effects on differentiation, cell migration and effector function. The possibility that these molecules may be therapeutic targets is also discussed.