RESEARCH ARTICLE


SLE Thrombocytopenia: From Peripheral Platelet Destruction to Central Hemopoietic Defect



Panayiotis D. Ziakas *
“Hygeia” Diagnostic & Therapeutic Centre. 9 Erythrou Stavrou St. 151 23 Athens, Greece


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© 2008 Ziakas et al.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

* Address correspondence to this author at the “Hygeia” Diagnostic & Therapeutic Centre. 9 Erythrou Stavrou St. 151 23 Athens, Greece; Tel: +30-210-6867311; Fax: +30-210-6867299; E-mail: zpanos@otenet.gr


Abstract

Thrombocytopenia in Systemic Lupus Erythematosus is a common clinical manifestation affecting up to one third of patients in published cohorts. Antiplatelet antibodies, antithrombopoietin antibodies and faulty hemopoiesis have been implicated among other immunologic and non-immunologic causes. This mini review is an uptodate summary of these immunologic phenomena.